Template:Sphere of Sapience strategy
Sphere of Sapience is a great card for combo decks, giving you at least four chances to filter your deck and draw combo pieces. Since this card doesn't actually give you any card advantage (and in fact costs card advantage and tempo to play), it's generally a poor choice for Tempo decks.
Druid players can use this weapon in Wild format to instantly break the 
Twig of the World Tree, instantly gaining 10 mana crystals at turn 5, or earlier with 
The Coin, 
Innervate, or 
Lightning Bloom. Likewise, other classes can use it to instantly activate the Deathrattles on their weapons, or counter bad RNG from cards like 
Blingtron 3000 giving you a weapon like a 
Cursed Blade.
This can also be an effective counter to Bomb Warrior, as you can choose to avoid drawing the Bombs. It also works well in Soul Fragment decks, since you can choose to draw/avoid Soul Fragments so you can save them up for cards like Soulciologist Malicia, or heal up in a pinch. This does have anti-synergy for Demon Hunters as it blocks their weapon and hero power, but is decent for Warlock decks.
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