Template:Knuckles strategy
Since Knuckles inflicts damage twice when he attacks a minion (one time to the minion, another to the enemy hero), he is a good minion to buff, similar to minions with Windfury. Knuckles synergises very well with the Grimy Goons' card-buffing mechanics for the same reason. He is also a Beast, which make him eligible to be enhanced by cards such as 
Houndmaster, Bestial Wrath, or 
Dire Frenzy.
Knuckles should always trade with a enemy minion since it will always attack the enemy hero providing both aggro and board control.
Knuckles is significantly more powerful when given Rush, allowing him to use his effect without waiting a turn. Houndmaster Shaw, 
Guardian Animals, Animated Broomstick, etc., effectively gives him Charge since he always deals damage to the enemy hero on attack.
The Beast Within and Trueaim Crescent forces Knuckles to attack and add more face damage.
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